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Welcome to O2H
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Welcome to O2H
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| Medicinal Chemistry |
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O2h has a wide range of expertise in medicinal chemistry to help accelerate the drug discovery process. O2h can provide medicinal chemistry input to hit-to-lead and lead optimisation projects as well as at the pre-clinical developmental stage. Specifically, the O2h team has demonstrated expertise in: | | | | Lead Generation | | | | • | Ligand design for pre-defined targets | | • | Synthesis of a homologous or diverse series of compounds for drug discovery projects | | • | Design and generation of libraries of structurally related compounds (close structural analogs, bioisosters etc.) | | • | Combinatorial synthesis of general as well as focused libraries | | • | Quick search for surrogates of core chemical scaffold. |
| | | | Lead Optimization and Structure Activity Relationship (SAR) studies | | | | • | Hit-to-lead and Lead optimization with consideration of prior art, patentability and other IP issues | | • | Computational chemistry and molecular modeling for the design of ligands | | • | Design of virtual library with chemical diversity | | • | Establishing structure-activity relationships | | • | Prioritizing compounds for in-vitro screening | | • | Generation of lead molecules using traditional/iterative medicinal chemistry approach |
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